Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMDW5ZC)

Drug Name
SER-100 Drug Info
Synonyms ORL1 receptor agonists, Zealand Pharma; ZP-120; ZP-120C
Indication
Disease Entry ICD 11 Status REF
Heart failure BD10-BD13 Phase 2 [1]
Cross-matching ID
PubChem CID
25086585
CAS Number
CAS 383123-18-0
TTD Drug ID
DMDW5ZC

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Nociceptin receptor (OPRL1) TTNT7K8 OPRX_HUMAN Agonist [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Nociceptin receptor (OPRL1) DTT OPRL1 4.86 4.72 4.162 4.692
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Heart failure
ICD Disease Classification BD10-BD13
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Nociceptin receptor (OPRL1) DTT OPRL1 1.75E-01 0.05 0.25
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 ClinicalTrials.gov (NCT00283361) ZP120 Add-on to Furosemide in Treatment of Acute or Sub-Acute Decompensated Heart Failure. U.S. National Institutes of Health.
2 Clinical pipeline report, company report or official report of Serodus ASA.