Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DME0WSR)

Drug Name
Pyrrolo[2,3-d]pyrimidine derivative 4 Drug Info
Synonyms PMID28270021-Compound-WO2012137089PF-06278121 (Example 9)
Indication
Disease Entry ICD 11 Status REF
Chronic pain MG30 Patented [1]
Neuropathic pain 8E43.0 Patented [1]
Pruritus EC90 Patented [1]
Solid tumour/cancer 2A00-2F9Z Patented [1]
Thymic cancer 2C27 Patented [1]
Cross-matching ID
TTD Drug ID
DME0WSR

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
BDNF/NT-3 growth factors receptor (TrkB) TTKN7QR NTRK2_HUMAN Inhibitor [1]
NT-3 growth factor receptor (TrkC) TTXABCW NTRK3_HUMAN Inhibitor [1]
Tropomyosin-related kinase A (TrkA) TTTDVOJ NTRK1_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
NT-3 growth factor receptor (TrkC) DTT NTRK3 7.27 6.435 6.1 6.863
Tropomyosin-related kinase A (TrkA) DTT NTRK1 0.848 1.138 2.293 2.722
BDNF/NT-3 growth factors receptor (TrkB) DTT NTRK2 4.65 5.231 6.555 4.672
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Chronic pain
ICD Disease Classification MG30
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
NT-3 growth factor receptor (TrkC) DTT NTRK3 7.06E-04 -0.14 -0.43
Tropomyosin-related kinase A (TrkA) DTT NTRK1 8.72E-01 -0.04 -0.22
BDNF/NT-3 growth factors receptor (TrkB) DTT NTRK2 3.06E-01 -0.15 -0.31
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849.