Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DME5IJQ)

Drug Name
CR-5259 Drug Info
Synonyms CR-4144 series; CR-4152 series; CR-4153 series; CR-4167 series; Aggrecanase (ADAMTS-4 and 5) inhibitors (osteoarthritis),Rottapharm Madaus
Indication
Disease Entry ICD 11 Status REF
Osteoarthritis FA00-FA05 Investigative [1]
Cross-matching ID
TTD Drug ID
DME5IJQ

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Aggrecanase (ADAMTS5) TTXSU2Y ATS5_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Aggrecanase (ADAMTS5) DTT ADAMTS5 5.527 6.073 5.885 6.287
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

ICD Disease Classification 15 Disease of the musculoskeletal system/connective tissue
Disease Class ICD-11: FA20 Rheumatoid arthritis
The Studied Tissue Synovial tissue
The Studied Disease Osteoarthritis [ICD-11:FA20]
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Aggrecanase (ADAMTS5) DTT ADAMTS5 6.40E-01 0.24 0.26
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1677).