Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMEFOV6)

Drug Name

2-phenyl-N-(pyridin-4-yl)quinazolin-4-amine Drug Info

Synonyms

CHEMBL564660; 2-phenyl-N-(pyridin-4-yl)quinazolin-4-amine; AC1O5DWY; SCHEMBL412953; QGWNGFYEPGNYNY-UHFFFAOYSA-N; MolPort-002-121-406; BDBM50293513; ZINC13633702; STL388203; AKOS003232028; AKOS002341780; MCULE-2242877238; 4-(4-pyridylamino)-2-penyl quinazoline; 4-(4-Pyridvlamino)-2-Phenyl Quinazoline; 4-(4-pyridylamino)-2-phenyl quinazoline

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 6456587
TTD Drug ID: DMEFOV6

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
TGF-beta receptor type I (TGFBR1)	TTP4520	TGFR1_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
TGF-beta receptor type I (TGFBR1)	DTT	TGFBR1	6.123	5.573	5.6	5.399

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
TGF-beta receptor type I (TGFBR1)	DTT	TGFBR1	2.62E-01	0.27	1.01

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Design of novel quinazoline derivatives and related analogues as potent and selective ALK5 inhibitors. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2277-81.