Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMEGAZS)

Drug Name
PMID24432909C8e Drug Info
Synonyms 4cd0; GTPL8137; ZINC98050687; BDBM50448785; NCGC00485046-01; P-355; AWJ
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
72710568
CAS Number
CAS 1549629-82-4
TTD Drug ID
DMEGAZS

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
ALK tyrosine kinase receptor (ALK) TTPMQSO ALK_HUMAN Inhibitor [1]
BDNF/NT-3 growth factors receptor (TrkB) TTKN7QR NTRK2_HUMAN Inhibitor [1]
Leukocyte receptor tyrosine kinase (LTK) TT1JZG6 LTK_HUMAN Inhibitor [1]
Proto-oncogene c-Fer (FER) TTRA9G0 FER_HUMAN Inhibitor [1]
Proto-oncogene c-Fes (FES) TTLBY21 FES_HUMAN Inhibitor [1]
Proto-oncogene c-Ros (ROS1) TTSZ6Y3 ROS1_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Proto-oncogene c-Ros (ROS1) DTT ROS1 5.511 4.406 4.973 4.823
ALK tyrosine kinase receptor (ALK) DTT ALK 5.329 3.897 4.178 4.943
BDNF/NT-3 growth factors receptor (TrkB) DTT NTRK2 4.65 5.231 6.555 4.672
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
BDNF/NT-3 growth factors receptor (TrkB) DTT NTRK2 3.06E-01 -0.15 -0.31
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Design of potent and selective inhibitors to overcome clinical anaplastic lymphoma kinase mutations resistant to crizotinib. J Med Chem.> 2014 Feb 27;57(4):1170-87.