Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMEH6LV)

• Drug Name: Fontolizumab Drug Info
• Synonyms: Fontolizumab (USAN/INN)

Indication

Disease Entry	ICD 11	Status	REF
Inflammatory bowel disease	DD72	Discontinued in Phase 2	[1]
Rheumatoid arthritis	FA20	Discontinued in Phase 2	[1]

• Cross-matching ID: TTD Drug ID: DMEH6LV

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Interferon-gamma (IFNG)	TT93WF5	IFNG_HUMAN	Not Available	[2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Interferon-gamma (IFNG)	DTT	IFNG	5.624	4.096	4.812	4.792

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Inflammatory bowel disease
• ICD Disease Classification: DD72

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Interferon-gamma (IFNG)	DTT	IFNG	3.25E-01	0.02	0.04

References

• [1] Emerging drugs for rheumatoid arthritis. Expert Opin Emerg Drugs. 2008 Mar;13(1):175-96.
• [2] Emerging drugs to treat Crohn's disease. Expert Opin Emerg Drugs. 2007 Mar;12(1):49-59.