Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMELXBQ)

Drug Name
PG-530742 Drug Info
Synonyms PG 116800; PG 530742; PGE 530742; PGE 7113313; PG-116800
Indication
Disease Entry ICD 11 Status REF
Myocardial infarction BA41-BA43 Discontinued in Phase 2 [1]
Osteoarthritis FA00-FA05 Discontinued in Phase 2 [1]
Cross-matching ID
PubChem CID
9848869
CAS Number
CAS 291533-11-4
TTD Drug ID
DMELXBQ

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Matrix metalloproteinase-3 (MMP-3) TTUZ2L5 MMP3_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Matrix metalloproteinase-3 (MMP-3) DTT MMP3 5.202 4.907 4.372 5.133
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Myocardial infarction
ICD Disease Classification BA41-BA43
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Matrix metalloproteinase-3 (MMP-3) DTT MMP3 2.22E-02 0.1 0.53
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Selective matrix metalloproteinase inhibition attenuates progression of left ventricular dysfunction and remodeling in dogs with chronic heart fail... Am J Physiol Heart Circ Physiol. 2006 Jun;290(6):H2522-7.