Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMEP80C)

Drug Name

1-(piperazin-1-yl)isoquinoline Drug Info

Synonyms

1-(piperazin-1-yl)isoquinoline; 126653-00-7; 1-Piperazine-1-yl-isoquinoline; 1-Piperazin-1-yl-isoquinoline; 1-(1-isoquinolinyl)piperazine; 1-(1-piperazinyl)isoquinoline; CHEMBL595552; Isoquinoline,1-(1-piperazinyl)-; Isoquinoline, 1-(1-piperazinyl)-; W-205253; 1-[1-Piperazinyl]isoquinoline; PubChem8306; ACMC-209ymu; piperazinohydroisoquinoline; 1-piperazin-1-ylisoquinoline; 1-Pyperazin-1-yl-isoquinoline; SCHEMBL2076366; TPC-A003; 1-(Isoquinolin-1-yl)piperazine; CTK4B5291; KS-00000JYY; IDFYLSABDUMICK-UHFFFAOYSA-N

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 15887436
TTD Drug ID: DMEP80C

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT 2C receptor (HTR2C)	TTWJBZ5	5HT2C_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
5-HT 2C receptor (HTR2C)	DTT	HTR2C	4.233	3.329	3.843	3.888

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
5-HT 2C receptor (HTR2C)	DTT	HTR2C	1.02E-02	-0.45	-0.37
5-HT 2C receptor (HTR2C)	DTT	HTR2C	2.27E-01	0.27	0.6

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Design and synthesis of orally-active and selective azaindane 5HT2c agonist for the treatment of obesity. Bioorg Med Chem Lett. 2010 Jan 1;20(1):266-71.