Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMEW62S)

Drug Name

AB-106 Drug Info

Synonyms

DS6051b; GTPL11198; AB106

Indication

Disease Entry	ICD 11	Status	REF
Non-small-cell lung cancer	2C25	Phase 2	[1]

Cross-matching ID

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Proto-oncogene c-Ros (ROS1)	TTSZ6Y3	ROS1_HUMAN	Inhibitor	[2]
Tropomyosin receptor kinase (Trk)	TTJOCTY	NTRK1_HUMAN; NTRK2_HUMAN; NTRK3_HUMAN	Inhibitor	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Proto-oncogene c-Ros (ROS1)	DTT	ROS1	5.511	4.406	4.973	4.823

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Non-small-cell lung cancer

ICD Disease Classification

2C25

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Proto-oncogene c-Ros (ROS1)	DTT	ROS1	1.45E-44	-1.01	-1.9

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	ClinicalTrials.gov (NCT04395677) A Study of AB-106 in Subjects With Advanced NSCLC Harboring ROS1 Fusion Gene. U.S. National Institutes of Health.
2	Clinical pipeline report, company report or official report of AnHeart Therapeutics.