General Information of Drug (ID: DMEWVG8)

Drug Name
PMID24900526C1 Drug Info
Synonyms
107491-28-1; AC1LHVED; BAS 06984707; CBKinase1_016190; CBKinase1_003790; MLS000124060; GTPL7870; CTK7J5343; MolPort-002-007-625; ZINC470145; MFCD03876460; BDBM50400562; AKOS000302705; MCULE-5295604199; SMR000124614; DB-016663; TR-042640; ST50281836
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
893637
TTD Drug ID
DMEWVG8

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Matrix metalloproteinase-12 (MMP-12) TTXZ0KQ MMP12_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Matrix metalloproteinase-12 (MMP-12) DTT MMP12 5.217 6.527 5.733 5.624
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Matrix metalloproteinase-12 (MMP-12) DTT MMP12 1.22E-106 5.08 3.56
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Target-Activated Prodrugs (TAPs) for the Autoregulated Inhibition of MMP12. ACS Med Chem Lett. 2012 Jul 14;3(8):653-7.