Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMEWVG8)

Drug Name

PMID24900526C1 Drug Info

Synonyms

107491-28-1; AC1LHVED; BAS 06984707; CBKinase1_016190; CBKinase1_003790; MLS000124060; GTPL7870; CTK7J5343; MolPort-002-007-625; ZINC470145; MFCD03876460; BDBM50400562; AKOS000302705; MCULE-5295604199; SMR000124614; DB-016663; TR-042640; ST50281836

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 893637
TTD Drug ID: DMEWVG8

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Matrix metalloproteinase-12 (MMP-12)	TTXZ0KQ	MMP12_HUMAN	Inhibitor	[1]

------------------------------------------------------------------------------------

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Matrix metalloproteinase-12 (MMP-12)	DTT	MMP12	5.217	6.527	5.733	5.624

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Matrix metalloproteinase-12 (MMP-12)	DTT	MMP12	1.22E-106	5.08	3.56

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Target-Activated Prodrugs (TAPs) for the Autoregulated Inhibition of MMP12. ACS Med Chem Lett. 2012 Jul 14;3(8):653-7.