Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMF3QN1)

• Drug Name: ALKS33 Drug Info
• Synonyms: Samidorphan

Indication

Disease Entry	ICD 11	Status	REF
Alcohol dependence	6C40.2	Phase 2	[1]

• Cross-matching ID:
  PubChem CID: 11667832
  CAS Number: CAS 852626-89-2
  TTD Drug ID: DMF3QN1

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Opioid receptor mu (MOP)	TTKWM86	OPRM_HUMAN	Inhibitor	[2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Opioid receptor mu (MOP)	DTT	OPRM1	4.548	5.062	4.652	4.776

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Alcohol dependence
• ICD Disease Classification: 6C40.2

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Opioid receptor mu (MOP)	DTT	OPRM1	5.94E-01	-0.02	-0.17

References

• [1] Clinical pipeline report, company report or official report of Alkermes.
• [2] Syntheses of novel high affinity ligands for opioid receptors. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2289-94.