Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMFAO5G)

Drug Name
S-PRAnt Drug Info
Synonyms S-PRAnt (symptoms of uterine fibroids)
Indication
Disease Entry ICD 11 Status REF
Uterine fibroids 2E86.0 Phase 2 [1]
Cross-matching ID
TTD Drug ID
DMFAO5G

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Progesterone receptor (PGR) TTUV8G9 PRGR_HUMAN Antagonist [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Progesterone receptor (PGR) DTT PGR 1.848 1.888 1.263 0.138
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Uterine fibroids
ICD Disease Classification 2E86.0
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Progesterone receptor (PGR) DTT PGR 3.26E-38 -3.79 -2.5
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800033040)
2 BAY 1002670: a novel, highly potent and selective progesterone receptor modulator for gynaecological therapies. Hum Reprod. 2013 Aug;28(8):2253-64.