Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMFC3B5)

Drug Name

2-phenyl-N-(1,3,4-thiadiazol-2-yl)acetamide Drug Info

Synonyms

2-phenyl-N-(1,3,4-thiadiazol-2-yl)acetamide; AC1LGHTG; CHEMBL225956; MolPort-002-561-993; MolPort-000-823-043; ZINC17043968; STK536010; AKOS002254375; MCULE-9751182652; 84954-79-0; ST50752086; Benzeneacetamide, N-1,3,4-thiadiazol-2-yl-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 821620
TTD Drug ID: DMFC3B5

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
LOX-5 messenger RNA (ALOX5 mRNA)	TTSJ6Q4	LOX5_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
LOX-5 messenger RNA (ALOX5 mRNA)	DTT	ALOX5	4.966	5.133	5.358	6.128

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
LOX-5 messenger RNA (ALOX5 mRNA)	DTT	ALOX5	9.43E-03	0.14	0.28

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Identification of natural-product-derived inhibitors of 5-lipoxygenase activity by ligand-based virtual screening. J Med Chem. 2007 May 31;50(11):2640-6.