Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMFG1YA)

Drug Name

177Lu-AMBA Drug Info

Synonyms

Ga67-AMBA; Ga68-AMBA; Galenium67-AMBA; Galenium68-AMBA; In111-AMBA; Indium-111-AMBA; Lutetium-111-AMBA; Gastrin releasing peptide receptor agonist (radiotherapeutic, cancer), Bracco; GRP-R agonist (radiotherapeutic, cancer), Bracco; 111In-AMBA; 177Lu-AMBA (cancer), Marillion Pharmaceuticals; 177Lu-DOTA-G-4-aminobenzoyl-QWAVGHLM-NH2; 67Ga-AMBA; 68Ga-AMBA

Indication

Disease Entry	ICD 11	Status	REF
Breast cancer	2C60-2C65	Phase 1	[1]

Cross-matching ID

TTD Drug ID: DMFG1YA

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Gastrin-releasing peptide receptor (GRPR)	TTC1MVT	GRPR_HUMAN	Agonist	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Gastrin-releasing peptide receptor (GRPR)	DTT	GRPR	6.837	6.612	6.835	6.559

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Breast cancer

ICD Disease Classification

2C60-2C65

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Gastrin-releasing peptide receptor (GRPR)	DTT	GRPR	6.26E-01	-0.29	-0.6

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800029232)
2	Multimodality imaging and preclinical evaluation of 177Lu-AMBA for human prostate tumours in a murine model. Anticancer Res. 2010 Oct;30(10):4039-48.