Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMFJPYV)

Drug Name
LSI-518P Drug Info
Synonyms HDL mimetics (atherosclerosis), Lipid Sciences
Indication
Disease Entry ICD 11 Status REF
Cardiovascular disease BA00-BE2Z Terminated [1]
Cross-matching ID
TTD Drug ID
DMFJPYV

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Apolipoprotein A-I (APOA1) TT7GN3U APOA1_HUMAN Modulator [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Apolipoprotein A-I (APOA1) DTT APOA1 13.036 4.508 4.982 12.009
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Cardiovascular disease
ICD Disease Classification BA00-BE2Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Apolipoprotein A-I (APOA1) DTT APOA1 8.72E-01 -0.03 -0.45
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 HDL mimetic peptide ATI-5261 forms an oligomeric assembly in solution that dissociates to monomers upon dilution. Biochemistry. 2011 May 17;50(19):4068-76.
2 Clinical review: The evolving role of HDL in the treatment of high-risk patients with cardiovascular disease. J Clin Endocrinol Metab. 2011 May;96(5):1246-57.