General Information of Drug (ID: DMFPNQ9)

Drug Name
4-(2-Oxo-2-phenyl-acetyl)-benzoic acid Drug Info
Synonyms
4-(2-oxo-2-phenylacetyl)benzoic acid; 72857-25-1; 4-(2-Oxo-2-phenyl-acetyl)-benzoic acid; MLS000775407; SMR000368487; Opera_ID_465; Benzil-based compound, 14; AC1M5V1J; CHEMBL370059; SCHEMBL2156860; 4-(oxophenylacetyl)benzoic acid; BDBM22736; CTK5D6959; DTXSID10368385; MolPort-000-510-282; HMS2753L08; 4-[oxo(phenyl)acetyl]benzoic acid; ZINC3269660; ZX-AL000632; STK246909; SBB039312; AKOS000267727; MCULE-7710064147; Benzoic acid,4-(2-oxo-2-phenylacetyl)-; KB-237683; ST50160330
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
2385968
CAS Number
CAS 72857-25-1
TTD Drug ID
DMFPNQ9

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Liver carboxylesterase (CES1) TTMF541 EST1_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Liver carboxylesterase (CES1) DTT CES1 12.04 6.525 5.311 5.909
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Liver carboxylesterase (CES1) DTT CES1 3.82E-08 1.86 1.9
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases. J Med Chem. 2005 Apr 21;48(8):2906-15.