Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMFTGHX)

Drug Name
Ad5CMV-NIS Drug Info
Synonyms Sodium iodide symporter adenoviral gene therapy (prostate cancer); Sodium iodide symporter adenoviral gene therapy (prostate cancer), Mayo Clinic
Indication
Disease Entry ICD 11 Status REF
Prostate cancer 2C82.0 Phase 1 [1]
Cross-matching ID
TTD Drug ID
DMFTGHX

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Sodium/iodide cotransporter (SLC5A5) TTW7HI9 SC5A5_HUMAN Modulator [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Sodium/iodide cotransporter (SLC5A5) DTT SLC5A5 7.754 7.029 7.351 6.322
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

ICD Disease Classification 02 Neoplasm
Disease Class ICD-11: 2C82 Prostate cancer
The Studied Tissue Prostate
The Studied Disease Prostate cancer [ICD-11:2C82]
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Sodium/iodide cotransporter (SLC5A5) DTT SLC5A5 7.01E-04 -1.48 -1.37
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 ClinicalTrials.gov (NCT00788307) Gene Therapy and Radioactive Iodine in Treating Patients With Locally Recurrent Prostate Cancer That Did Not Respond to External-Beam Radiation Therapy. U.S. NationalInstitutes of Health.
2 Noninvasive Imaging and Radiovirotherapy of Prostate Cancer Using an Oncolytic Measles Virus Expressing the Sodium Iodide Symporter. Mol Ther. 2009 December; 17(12): 2041-2048.