Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMFXB21)

Drug Name

1,2-Di-p-tolyl-ethane-1,2-dione Drug Info

Synonyms

4,4'-Dimethylbenzil; 3457-48-5; 1,2-Di-p-tolylethane-1,2-dione; p-Tolil; 1,2-bis(4-methylphenyl)ethane-1,2-dione; Ethanedione, bis(4-methylphenyl)-; 4,4'-Dimethyldibenzoyl; Ethandione, bis(p-tolyl)-; 1,2-dip-tolylethane-1,2-dione; BCWCEHMHCDCJAD-UHFFFAOYSA-N; MFCD00008554; AK105959; 1,2-Bis(4-methylphenyl)-1,2-ethanedione; AE-562/06268025; Di-p-tolylethanedione; EINECS 222-388-2; AC1Q5DTX; ACMC-209i8d; AC1L2S4L; Benzil-based compound, 18; SCHEMBL167254; 4,4'-Dimethylbenzil, 97%; CHEMBL192625; BDBM22740; DTXSID60188116

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 76996
CAS Number: CAS 3457-48-5
TTD Drug ID: DMFXB21

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Liver carboxylesterase (CES1)	TTMF541	EST1_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Liver carboxylesterase (CES1)	DTT	CES1	12.04	6.525	5.311	5.909

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Liver carboxylesterase (CES1)	DTT	CES1	3.82E-08	1.86	1.9

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases. J Med Chem. 2005 Apr 21;48(8):2906-15.