Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMFZ2PI)

Drug Name

6-bromo-5-methyl-1H-indole-2,3-dione Drug Info

Synonyms

6-bromo-5-methyl-1H-indole-2,3-dione; 6-BROMO-5-METHYLISATIN; 306325-13-3; 6-bromo-5-methylindoline-2,3-dione; 6-bromo-5-methyl-2,3-dihydro-1H-indole-2,3-dione; 6-bromo-5-methyl-1H-benzo[d]azolidine-2,3-dione; AC1LW5IO; CBMicro_014209; Isatin-based compound, 58; SCHEMBL5526009; AC1Q2O90; CHEMBL221830; ARONIS016716; CTK7H5981; BDBM22838; BBC/891; MolPort-001-022-207; DQZFCBOXZKQQPM-UHFFFAOYSA-N; ALBB-012856; ZX-AN011645; ZINC2052963; SMSF0004612; STK042825; SBB071631; AKOS000484014; MCULE-6005372434; FCH1317267; CB09212; KS-000049B7

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 1718647
TTD Drug ID: DMFZ2PI

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Liver carboxylesterase (CES1)	TTMF541	EST1_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Liver carboxylesterase (CES1)	DTT	CES1	12.04	6.525	5.311	5.909

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Liver carboxylesterase (CES1)	DTT	CES1	3.82E-08	1.86	1.9

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. J Med Chem. 2007 Apr 19;50(8):1876-85.