Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMG0I6L)

Drug Name

97-139 Drug Info

Synonyms

S-0139; SB-737004; 737004; [4aS-(4abeta,6aalpha,6bbeta,12abeta,14bbeta]-6a-[3-[2-(3-Carboxy-2(E)-propenamido)-5-hydroxyphenyl]-2(E)-propenoyloxymethyl]-2,2,6b,9,9.12a-hexamethyl-10-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a

Indication

Disease Entry	ICD 11	Status	REF
Cerebrovascular disease	8B2Z	Discontinued in Phase 2	[1]

Cross-matching ID

TTD Drug ID: DMG0I6L

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Endothelin A receptor (EDNRA)	TTKRD0G	EDNRA_HUMAN	Antagonist	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Endothelin A receptor (EDNRA)	DTT	EDNRA	3.776	4.505	5.121	3.536

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Cerebrovascular disease

ICD Disease Classification

8B2Z

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Endothelin A receptor (EDNRA)	DTT	EDNRA	3.19E-05	-2.69	-1.71

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009311)
2	S-0139 (Shionogi). Curr Opin Investig Drugs. 2002 Jul;3(7):1051-6.