Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMG594K)

Drug Name
KM-01221 Drug Info
Synonyms Chymase inhibitors (cardiovascular disease); KM-06864; MWP-00965; TY-51076; Chymase inhibitors (cardiovascular disease), Toa Eiyo
Indication
Disease Entry ICD 11 Status REF
Cardiovascular disease BA00-BE2Z Investigative [1]
Cross-matching ID
PubChem CID
2819266
TTD Drug ID
DMG594K

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Chymase (CYM) TT8VUE0 CMA1_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Chymase (CYM) DTT CMA1 2.848 4.517 4.615 3.406
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Cardiovascular disease
ICD Disease Classification BA00-BE2Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Chymase (CYM) DTT CMA1 3.36E-05 -0.62 -3.21
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2340).