Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMG7UPR)

Drug Name
Gamma-secretase modulators Drug Info
Synonyms Gamma-secretase modulators (Alzheimer's disease); Gamma-secretase modulators (Alzheimer's disease), F Hoffmann-La Roche
Indication
Disease Entry ICD 11 Status REF
Alzheimer disease 8A20 Investigative [1]
Cross-matching ID
PubChem CID
24781184
CAS Number
CAS 937812-80-1
TTD Drug ID
DMG7UPR

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Amyloid beta A4 protein (APP) TTE4KHA A4_HUMAN Modulator [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Amyloid beta A4 protein (APP) DTT APP 6.473 8.014 8.631 7.57
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Alzheimer disease
ICD Disease Classification 8A20
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Amyloid beta A4 protein (APP) DTT APP 1.60E-02 -0.07 -0.31
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Novel -secretase enzyme modulators directly target presenilin protein. J Biol Chem. 2011 Oct 28;286(43):37181-6
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2402).