Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMGB97I)

Drug Name

(biphenyl-3-ylamino)methylenediphosphonic acid Drug Info

Synonyms

CHEMBL55371; AC1NQQUY; (biphenyl-3-ylamino)methylenediphosphonic acid; BPH-218; NSC725581; BDBM50138040; ZINC13532369; NSC-725581; [(3-phenylanilino)-phosphonomethyl]phosphonic acid; [(3-phenylanilino)-phosphono-methyl]phosphonic acid; [(Biphenyl-3-ylamino)-phosphono-methyl]-phosphonic acid; (Biphenyl-3-yl)- aminomethylene-1,1-bisphosphonate (dihydrate); Phosphonic acid, [([1,1'-biphenyl]-3-ylamino)methylene]bis-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 5277466
TTD Drug ID: DMGB97I

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Geranyltranstransferase (FDPS)	TTIKWV4	FPPS_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Geranyltranstransferase (FDPS)	DTT	FDPS	7.06E-03	-0.73	-2.57

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Bisphosphonate inhibitors of ATP-mediated HIV-1 reverse transcriptase catalyzed excision of chain-terminating 3'-azido, 3'-deoxythymidine: a QSAR i... Bioorg Med Chem. 2008 Oct 1;16(19):8959-67.