Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMGCHW9)

Drug Name
Benzo(b)carbazol-11-one compound 2 Drug Info
Synonyms PMID27646564-Compound-10-1
Cross-matching ID
TTD Drug ID
DMGCHW9

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Proto-oncogene c-Ret (RET) TT4DXQT RET_HUMAN Inhibitor [1]
RET G691S mutant (RET G691S) TTY0WT7 RET_HUMAN Inhibitor [1]
RET M918T mutant (RET M918T) TT5XA6U RET_HUMAN Inhibitor [1]
RET S891A mutant (RET S891A) TT8BF4A RET_HUMAN Inhibitor [1]
RET V804L mutant (RET V804L) TT2RTDH RET_HUMAN Inhibitor [1]
RET V804M mutant (RET V804M) TTQV3NX RET_HUMAN Inhibitor [1]
RET Y791F mutant (RET Y791F) TTB0IO2 RET_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Proto-oncogene c-Ret (RET) DTT RET 5.459 5.43 4.256 4.322
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Proto-oncogene c-Ret (RET) DTT RET 9.18E-01 -0.36 -0.48
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 RET kinase inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jan;27(1):91-99.