Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMGCOQF)

Drug Name

AM-156 Drug Info

Synonyms

AM-206; AM-432; CRTH2 receptor antagonists (oral, allergic rhinitis); CRTH2 receptor antagonists (oral, allergic rhinitis), Amira Pharmaceuticals; CRTH2 antagonists (COPD/asthma/allergic rhinitis), Amira; DP2 antagonists (COPD/asthma/allergic rhinitis), Amira; Prostaglandin D2 (PGD2) antagonists (COPD/asthma/allergic rhinitis), Amira

Indication

Disease Entry	ICD 11	Status	REF
Allergic rhinitis	CA08.0	Investigative	[1]

Cross-matching ID

PubChem CID: 46702966
CAS Number: CAS 1224977-85-8
TTD Drug ID: DMGCOQF

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Prostaglandin D2 receptor 2 (PTGDR2)	TTQDMX5	PD2R2_HUMAN	Antagonist	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Prostaglandin D2 receptor 2 (PTGDR2)	DTT	PTGDR2	4.436	5.954	4.217	4.641

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Allergic rhinitis

ICD Disease Classification

CA08.0

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Prostaglandin D2 receptor 2 (PTGDR2)	DTT	PTGDR2	6.11E-02	-0.15	-0.25

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 339).