Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMGEVBH)

Drug Name

Aminothiazoline Drug Info

Synonyms

2-AMINOTHIAZOLE; aminothiazole; 96-50-4; thiazol-2-amine; 2-Thiazolamine; 1,3-Thiazol-2-amine; 2-Thiazolylamine; Abadole; Basedol; Abadol; 2-Thiazylamine; 4-Thiazolin-2-onimine; 2-Amino-1,3-thiazole; Aminothiazol; Aminotiazol; Aminothiazolum; Thiazole, 2-amino-; 2-Aminothiazol; 2-amino thiazole; USAF EK-P-5501; Aminothiazole [INN]; Aminotiazolo [DCIT]; Thiazolamine; RP 2921; Aminothiazol [INN-French]; Aminotiazol [INN-Spanish]; NSC 1900; Aminothiazolum [INN-Latin]; Thiazol-2-ylamine; UNII-5K8WKN668K; CCRIS 1279; 2-Aminothiazole, 97%

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 2155
ChEBI ID: CHEBI:40782
CAS Number: CAS 96-50-4
TTD Drug ID: DMGEVBH

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Nitric-oxide synthase inducible (NOS2)	TTF10I9	NOS2_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Nitric-oxide synthase inducible (NOS2)	DTT	NOS2	4.95	5.198	4.573	5.121

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Nitric-oxide synthase inducible (NOS2)	DTT	NOS2	4.24E-02	-0.27	-0.88

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	The design, synthesis and biological evaluation of 7-alkoxy-4-heteroarylamino-3-cyanoquinolines as dual inhibitors of c-Src and iNOS. Bioorg Med Chem Lett. 2008 Dec 1;18(23):6206-9.