Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMGN4OQ)

Drug Name

ISIS-1939 Drug Info

Synonyms

136216-59-6

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Intercellular adhesion molecule ICAM-1 (ICAM1)	TTCT6F7	ICAM1_HUMAN	Modulator	[1]

------------------------------------------------------------------------------------

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Intercellular adhesion molecule ICAM-1 (ICAM1)	DTT	ICAM1	7.993	5.81	6.662	5.926

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Intercellular adhesion molecule ICAM-1 (ICAM1)	DTT	ICAM1	5.21E-01	0.38	0.32

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Antisense oligonucleotides inhibit intercellular adhesion molecule 1 expression by two distinct mechanisms. J Biol Chem. 1991 Sep 25;266(27):18162-71.