Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMGO2D7)

Drug Name
3-acetyl-11-keto-beta-boswellic acid Drug Info
Synonyms
AKBA; 67416-61-9; 3-O-Acetyl-11-keto-beta-Boswellic Acid; AKbetaBA; UNII-BS16QT99Q1; Acetyl-11-keto-beta-boswellic acid; CHEMBL237111; BS16QT99Q1; Acetyl-11-keto--boswellic acid; AKBA cpd; Acetyl-11-keto-b-boswellic acid; acetyl-11-ketoboswellic acid; Acetyl-11-keto-beta-Boswellic Acid, Boswellia serrata; 3-Acetyl-11-keto-; 3alpha-acetoxy-11-keto-beta-boswellic acid; Curator_000001; MolPort-020-005-785; HMMGKOVEOFBCAU-BCDBGHSCSA-N
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
11168203
ChEBI ID
CHEBI:166842
CAS Number
CAS 67416-61-9
TTD Drug ID
DMGO2D7

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) TTN7BL9 DHI1_HUMAN Inhibitor [1]
Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) TT9H85R DHI2_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DTT HSD11B1 10.967 5.178 5.865 6.377
Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) DTT HSD11B2 2.7 9.856 9.113 6.857
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DTT HSD11B1 2.03E-01 -0.01 -0.08
Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) DTT HSD11B2 1.65E-01 -0.18 -1.16
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 11beta-Hydroxysteroid dehydrogenase 1 inhibiting constituents from Eriobotrya japonica revealed by bioactivity-guided isolation and computational a... Bioorg Med Chem. 2010 Feb 15;18(4):1507-15.