Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMGSNU4)

Drug Name

NE-10575 Drug Info

Synonyms

NE-10575; CHEMBL99553; 3-(2-Hydroxy-2,2-Diphosphonoethyl)-1-Methylpyridinium; GTPL3184; SCHEMBL8384475; BDBM50373099; NE 10575; 3-(2-hydroxy-2,2-diphosphonoethyl)-1-methylpyridin-1-ium; [1-Hydroxy-2-(1-methylpyridinium-3-yl)ethylidene]bisphosphonic acid

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 9847474
TTD Drug ID: DMGSNU4

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Geranyltranstransferase (FDPS)	TTIKWV4	FPPS_HUMAN	Inhibitor	[2]

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The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Geranyltranstransferase (FDPS)	DTT	FDPS	7.06E-03	-0.73	-2.57

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3184).
2	Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of hu... J Med Chem. 2008 Apr 10;51(7):2187-95.