Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMGSRLA)

Drug Name

GNF-PF-1967 Drug Info

Synonyms

GNF-PF-1967; AC1NEHJX; CHEMBL374744; MolPort-007-587-747; AKOS021661170; AKOS001495347; MCULE-7181472168; SR-01000549442; SR-01000549442-1; N-[2-(diethylamino)ethyl]-2-(4-fluorobenzyl)-3-(4-methoxyphenyl)-1-oxo-1,2,3,4-tetrahydroisoquinoline-4-carboxamide

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 4617502
TTD Drug ID: DMGSRLA

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Voltage-gated calcium channel alpha Cav3.2 (CACNA1H)	TTZPWGN	CAC1H_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Voltage-gated calcium channel alpha Cav3.2 (CACNA1H)	DTT	CACNA1H	3.485	2.536	3.524	3.511

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Voltage-gated calcium channel alpha Cav3.2 (CACNA1H)	DTT	CACNA1H	1.31E-04	-0.76	-2.12

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	3D pharmacophore based virtual screening of T-type calcium channel blockers. Bioorg Med Chem. 2007 Jan 15;15(2):1091-105.