Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMGSRN1)

Drug Name
Mipomersen Drug Info
Synonyms Mipomersen
Indication
Disease Entry ICD 11 Status REF
Familial hypercholesterolemia 5C80.00 Approved [1]
Therapeutic Class
Antisense
Cross-matching ID
PubChem CID
71301230
CAS Number
CAS 1000120-98-8
TTD Drug ID
DMGSRN1

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
APOB messenger RNA (APOB mRNA) TTN1IE2 APOB_HUMAN Not Available [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
APOB messenger RNA (APOB mRNA) DTT APOB 12.307 5.638 5.792 11.706
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

ICD Disease Classification 05 Endocrine, nutritional or metabolic disease
Disease Class ICD-11: 5A11 Type 2 diabetes mellitus
The Studied Tissue Whole blood
The Studied Disease Familial hypercholesterolemia [ICD-11:5A11]
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
APOB messenger RNA (APOB mRNA) DTT APOB 9.53E-01 0.03 0.18
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7364).
2 Design and development of antisense drugs. Expert Opin. Drug Discov. 2008 3(10):1189-1207.