Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMGTAWC)

Drug Name
RKI-1447 Drug Info
Synonyms RKI1447; compound 5g [PMID 23275831]
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
60138149
TTD Drug ID
DMGTAWC

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
CDC42 binding protein kinase alpha (DMPK-like alpha) TT5Z0EF MRCKA_HUMAN Inhibitor [1]
DMPK messenger RNA (DMPK mRNA) TTZQTY2 DMPK_HUMAN Inhibitor [1]
LIM domain kinase-1 (LIMK-1) TTWL9TY LIMK1_HUMAN Inhibitor [1]
Myosin light kinase (MYLK) TT18ETS MYLK_HUMAN Inhibitor [1]
PAK-1 protein kinase (PAK1) TTFN95D PAK1_HUMAN Inhibitor [1]
Protein kinase N1 (PKN1) TTSL41O PKN1_HUMAN Inhibitor [1]
Rho-associated protein kinase 1 (ROCK1) TTZN7RP ROCK1_HUMAN Inhibitor [1]
Rho-associated protein kinase 2 (ROCK2) TTGWKQJ ROCK2_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Rho-associated protein kinase 2 (ROCK2) DTT ROCK2 7.074 6.954 7.046 6.77
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Rho-associated protein kinase 2 (ROCK2) DTT ROCK2 1.55E-01 0.12 0.71
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinases (ROCK1 and 2). Medchemcomm. 2012 Jun 1;3(6):699-709.