Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMGTL8Z)

Drug Name

ZP-1848 Drug Info

Synonyms

Glucagon-like peptide-2 analog (inflammatory bowel disease/ Crohn's disease), Zealand

Indication

Disease Entry	ICD 11	Status	REF
Inflammatory bowel disease	DD72	Phase 1	[1]

Cross-matching ID

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glucagon-like peptide 2 receptor (GLP2R)	TT1YWO5	GLP2R_HUMAN	Modulator	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Glucagon-like peptide 2 receptor (GLP2R)	DTT	GLP2R	1.807	2.138	2.202	2.632

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Inflammatory bowel disease

ICD Disease Classification

DD72

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Glucagon-like peptide 2 receptor (GLP2R)	DTT	GLP2R	6.12E-01	0.06	0.3

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	ClinicalTrials.gov (NCT00868660) Healthy Normal Single Ascending Dose and Crohn's Patient Multiple Ascending Dose.
2	US patent application no. 8,580,918, Peptidic glp-2 agonists.