Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMH1W8F)

Drug Name	PMID27774824-Compound-Figure11Example1up Drug Info
Cross-matching ID	TTD Drug ID DMH1W8F

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
JAK-STAT signaling pathway (JAK-STAT pathway)	TTKAWRQ	NOUNIPROTAC	Inhibitor	[1]
Janus kinase 1 (JAK-1)	TT6DM01	JAK1_HUMAN	Inhibitor	[1]
Janus kinase 2 (JAK-2)	TTRMX3V	JAK2_HUMAN	Inhibitor	[1]
Janus kinase 3 (JAK-3)	TTT7PJU	JAK3_HUMAN	Inhibitor	[1]
TYK2 tyrosine kinase (TYK2)	TTBYWP2	TYK2_HUMAN	Inhibitor	[1]
Tyrosine-protein kinase (PTK)	TTJSQEF	NOUNIPROTAC	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Janus kinase 3 (JAK-3)	DTT	JAK3	2.104	3.248	2.848	4.485
Janus kinase 2 (JAK-2)	DTT	JAK2	4.957	5.257	4.986	4.784
Janus kinase 1 (JAK-1)	DTT	JAK1	8.621	9.012	9.168	8.535

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Janus kinase 3 (JAK-3)	DTT	JAK3	2.54E-02	-0.19	-0.51
Janus kinase 2 (JAK-2)	DTT	JAK2	4.84E-01	-0.03	-0.07
Janus kinase 1 (JAK-1)	DTT	JAK1	2.16E-02	-0.21	-0.36

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143.