Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMH4C3M)

Drug Name
STA-5326 Drug Info
Synonyms Apilimod; STA 5326; STA5326; N-[(3-methylphenyl)methylideneamino]-6-morpholin-4-yl-2-(2-pyridin-2-ylethoxy)pyrimidin-4-amine
Indication
Disease Entry ICD 11 Status REF
Crohn disease DD70 Phase 2 [1]
Rheumatoid arthritis FA20 Phase 2 [1]
Cross-matching ID
PubChem CID
10173277
CAS Number
CAS 541550-19-0
TTD Drug ID
DMH4C3M

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Interleukin-12 alpha (IL12A) TTRTK6Y IL12A_HUMAN Inhibitor [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Interleukin-12 alpha (IL12A) DTT IL12A 5.206 4.358 4.154 4.868
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Crohn disease
ICD Disease Classification DD70
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Interleukin-12 alpha (IL12A) DTT IL12A 2.41E-04 -0.12 -0.49
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 A phase 1/2A trial of STA 5326, an oral interleukin-12/23 inhibitor, in patients with active moderate to severe Crohn's disease. Inflamm Bowel Dis. 2006 Jul;12(7):558-65.
2 Therapeutic effect of the potent IL-12/IL-23 inhibitor STA-5326 on experimental autoimmune uveoretinitis. Arthritis Res Ther. 2008;10(5):R122.