Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMH9RGV)

Drug Name

TTP-814 Drug Info

Synonyms

PTP-1B inhibitors (oral, type 2 diabetes), TransTech Pharma

Indication

Disease Entry	ICD 11	Status	REF
Diabetic complication	5A2Y	Phase 1/2	[1]

Cross-matching ID

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Protein-tyrosine phosphatase 1B (PTP1B)	TTMS7KP	PTN1_HUMAN	Inhibitor	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Protein-tyrosine phosphatase 1B (PTP1B)	DTT	PTPN1	3.667	2.293	2.609	4.573

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Diabetic complication

ICD Disease Classification

5A2Y

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Protein-tyrosine phosphatase 1B (PTP1B)	DTT	PTPN1	9.44E-01	7.21E-03	0.08

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021204)
2	Protein tyrosine phosphatase 1B (PTP-1B; PTPN1). SciBX 5(7); doi:10.1038/scibx.2012.176. Feb. 16 2012