Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMHC32M)

Drug Name
N8,2-dihydroxy-N1-phenyloctanediamide Drug Info
Synonyms CHEMBL251009; N8,2-dihydroxy-N1-phenyloctanediamide; SCHEMBL8144564
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
25065929
TTD Drug ID
DMHC32M

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Histone deacetylase 2 (HDAC2) TTSHTOI HDAC2_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Histone deacetylase 2 (HDAC2) DTT HDAC2 5.815 7.561 7.044 7.334
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Histone deacetylase 2 (HDAC2) DTT HDAC2 8.48E-01 -7.29E-04 -4.65E-03
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Omega-alkoxy analogues of SAHA (vorinostat) as inhibitors of HDAC: a study of chain-length and stereochemical dependence. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6261-5.