Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMHDYBN)

Drug Name

RS-102,221 Drug Info

Synonyms

RS-102221; RS102221; 185376-97-0; RS 102221 HCl; Tocris-1050; RS-102,221; Biomol-NT_000133; AC1MW45U; GTPL187; CHEMBL88402; SCHEMBL7107338; BPBio1_000243; RS102221 HCl; CHEBI:93519; BDBM85098; HZZZZODVDSHQRG-UHFFFAOYSA-N; BCP03496; ZINC26580328; PDSP1_001633; PDSP2_001617; NCGC00024967-02; NCGC00024967-01; L000523; BRD-K87048468-003-01-9; N-{5-[5-(2,4-dioxo -1,3,8-triazaspiro[4.5]dec-8-yl)pentanoyl]-2,4-dimethoxyphenyl}-4-trifluoromethylbenzenesulfonamide

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 3693566
ChEBI ID: CHEBI:93519
CAS Number: CAS 185376-97-0
TTD Drug ID: DMHDYBN

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT 2C receptor (HTR2C)	TTWJBZ5	5HT2C_HUMAN	Inhibitor	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
5-HT 2C receptor (HTR2C)	DTT	HTR2C	4.233	3.329	3.843	3.888

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
5-HT 2C receptor (HTR2C)	DTT	HTR2C	1.02E-02	-0.45	-0.37
5-HT 2C receptor (HTR2C)	DTT	HTR2C	2.27E-01	0.27	0.6

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 187).
2	cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain... J Med Chem. 2008 Nov 27;51(22):7094-8.