Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMHE804)

• Drug Name: LOTRAFIBAN Drug Info
• Synonyms: Lotrafiban; SB 214857; UNII-KLQ306I83X; 171049-14-2; SB-214857; CHEMBL356301; KLQ306I83X; DSSTox_CID_31391; R-Lotrafiban; Lotrafiban [INN]; AC1L2Z4G; DSSTox_RID_97278; DSSTox_RID_97279; DSSTox_GSID_57602; DSSTox_GSID_57603; SCHEMBL29596; CAS-NOCAS_57603; DTXSID7057602; ZINC3812598; Tox21_113990; Tox21_113989; BDBM50054825; SB-214857A; NCGC00319023-02; NCGC00319023-01; (2S)-7-((4,4'-Bipiperidin)-1-ylcarbonyl)-2,3,4,5-tetrahydro-4-methyl-3-oxo-1H-1,4-benzodiazepine-2-acetic acid; KB-80491; SB-214134; CAS-171049-14-2

Indication

Disease Entry	ICD 11	Status	REF
Cardiovascular disease	BA00-BE2Z	Discontinued in Phase 3	[1]

• Cross-matching ID:
  PubChem CID: 80274
  CAS Number: CAS 171049-14-2
  TTD Drug ID: DMHE804

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glycoprotein IIb/IIIa receptor (GPIIb/IIIa)	TT38RM1	ITA2B_HUMAN; ITB3_HUMAN	Modulator	[2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Glycoprotein IIb/IIIa receptor (GPIIb/IIIa)	DTT	ITGA2B	2.186	1.202	1.585	2.7

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Cardiovascular disease
• ICD Disease Classification: BA00-BE2Z

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Glycoprotein IIb/IIIa receptor (GPIIb/IIIa)	DTT	ITGA2B; ITGB3	7.83E-01	-0.11	-0.45

References

• [1] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004570)
• [2] Lotrafiban: an oral platelet glycoprotein IIb/IIIa blocker.Expert Opin Investig Drugs.2000 Nov;9(11):2673-87.