Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMHF4IQ)

Drug Name

Trimethaphan Drug Info

Synonyms

Thimethaphan; Trimetaphan; Trimetaphanum; Arfonad (TN); Thieno(1',2':1,2)thieno(3,4-d)imidazol-5-ium, decahydro-2-oxo-1,3-bis(phenylmethyl)-(VAN); 1,3-dibenzyl-2-oxodecahydrothieno[1',2':1,2]thieno[3,4-d]imidazol-5-ium

Indication

Disease Entry	ICD 11	Status	REF
Aneurysm	BD51.Z	Approved	[1]
Hypertensive emergency	BA03	Approved	[1]

Therapeutic Class

Antihypertensive Agents

Cross-matching ID

PubChem CID: 23576
ChEBI ID: CHEBI:9728
CAS Number: CAS 7187-66-8
TTD Drug ID: DMHF4IQ

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Neuronal acetylcholine receptor alpha-4 (CHRNA4)	TT4H1MQ	ACHA4_HUMAN	Antagonist	[2]

------------------------------------------------------------------------------------

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Neuronal acetylcholine receptor alpha-4 (CHRNA4)	DTT	CHRNA4	4.409	3.585	4.385	4.591

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Aneurysm

ICD Disease Classification

BD51.Z

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Neuronal acetylcholine receptor alpha-4 (CHRNA4)	DTT	CHRNA4	3.51E-10	-0.15	-0.61

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Drug information of Trimethaphan, 2008. eduDrugs.
2	Mechanism of long-lasting block of ganglion nicotinic receptors by mono-ammonium compounds with long aliphatic chain. J Auton Nerv Syst. 1994 Aug;48(3):231-40.