Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMHG7DZ)

Drug Name
UltraCD40L Drug Info
Synonyms SP-D-CD40L; 4-trimer SP-D-CD40L (anticancer, adjuvant), Multimeric Biotherapeutics
Indication
Disease Entry ICD 11 Status REF
Systemic lupus erythematosus 4A40.0 Phase 1 [1]
Cross-matching ID
TTD Drug ID
DMHG7DZ

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
TNF related activation protein (CD40LG) TTIJP3Q CD40L_HUMAN Modulator [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
TNF related activation protein (CD40LG) DTT CD40LG 3.573 2.406 3.632 3.733
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Systemic lupus erythematosus
ICD Disease Classification 4A40.0
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
TNF related activation protein (CD40LG) DTT CD40LG 8.02E-01 -0.13 -0.7
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Soluble multi-trimeric TNF superfamily ligand adjuvants enhance immune responses to a HIV-1 Gag DNA vaccine. Vaccine. 2012 January 17; 30(4): 691-702.
2 CD40L-Tri, a novel formulation of recombinant human CD40L that effectively activates B cells. Cancer Immunol Immunother. 2013 February; 62(2): 347-357.