Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMHJV0X)

Drug Name
Pertuzumab Drug Info
Synonyms Pertuzumab (genetical recombination); Pertuzumab (USAN/INN); Pertuzumab (genetical recombination) (JAN); Pertuzumab (ERBB2 mAb inhibitor)
Indication
Disease Entry ICD 11 Status REF
Adrenal gland neoplasm Approved [1]
Breast cancer 2C60-2C65 Approved [2]
Neuroblastoma 2D11.2 Investigative [1]
Cross-matching ID
TTD Drug ID
DMHJV0X

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Erbb2 tyrosine kinase receptor (HER2) TT6EO5L ERBB2_HUMAN Inhibitor [3]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Erbb2 tyrosine kinase receptor (HER2) DTT ERBB2 6.226 7.169 7.196 6.397
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Adrenal gland neoplasm
ICD Disease Classification
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Erbb2 tyrosine kinase receptor (HER2) DTT ERBB2 2.78E-03 0.59 4.11
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 A standard database for drug repositioning. Sci Data. 2017 Mar 14;4:170029.
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5046).
3 Clinical pipeline report, company report or official report of Roche (2009).