Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMHR1A7)

• Drug Name: LAMIFIBAN Drug Info
• Synonyms: Lamifiban; UNII-9XOE28082S; Ro-44-9883; CHEMBL108111; 144412-49-7; 9XOE28082S; Lamifiban [USAN:INN]; Ro 44-9883/000; Lamstat; AC1MI4XF; SCHEMBL4683; ((1-(N-(p-Amidinobenzoyl)-L-tyrosyl)-4-piperidyl)oxy)acetic acid; FPKOGTAFKSLZLD-FQEVSTJZSA-N; 2-[1-[2-[(4-carbamimidoylbenzoyl)amino]-3-(4-hydroxyphenyl)propanoyl]piperidin-4-yl]oxyacetic acid; Acetic acid, ((1-(2-((4-(aminoiminomethyl)benzoyl)amino)-3-(4-hydroxyphenyl)-1-oxopropyl)-4-piperidinyl)oxy)-, (S)-; Acetic acid, ((1-(2-((4-aminoiminomethyl)benzoyl)amino)-3-(4-hydro

Indication

Disease Entry	ICD 11	Status	REF
Angina pectoris	BA40	Discontinued in Phase 3	[1]

• Cross-matching ID:
  PubChem CID: 3038484
  CAS Number: CAS 144412-49-7
  TTD Drug ID: DMHR1A7

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glycoprotein IIb/IIIa receptor (GPIIb/IIIa)	TT38RM1	ITA2B_HUMAN; ITB3_HUMAN	Modulator	[2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Glycoprotein IIb/IIIa receptor (GPIIb/IIIa)	DTT	ITGA2B	2.186	1.202	1.585	2.7

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Angina pectoris
• ICD Disease Classification: BA40

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Glycoprotein IIb/IIIa receptor (GPIIb/IIIa)	DTT	ITGA2B; ITGB3	7.83E-01	-0.11	-0.45

References

• [1] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003532)
• [2] Lamifiban. Drugs. 1999 Feb;57(2):215-21; discussion 222-3.