Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMHXJV2)

Drug Name
SM-16 Drug Info
Synonyms TGF-beta receptor inhibitors, Biogen; TGF-beta receptor inhibitors, Biogen Idec
Indication
Disease Entry ICD 11 Status REF
Fibrosis GA14-GC01 Terminated [1]
Cross-matching ID
TTD Drug ID
DMHXJV2

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
TGF-beta receptor type I (TGFBR1) TTP4520 TGFR1_HUMAN Inhibitor [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
TGF-beta receptor type I (TGFBR1) DTT TGFBR1 6.123 5.573 5.6 5.399
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Fibrosis
ICD Disease Classification GA14-GC01
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
TGF-beta receptor type I (TGFBR1) DTT TGFBR1 2.62E-01 0.27 1.01
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026469)
2 TGF-beta type I receptor kinase inhibitor down-regulates rheumatoid synoviocytes and prevents the arthritis induced by type II collagen antibody. Int Immunol. 2007 Feb;19(2):117-26.