Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMI1XQ9)

Drug Name

RG7697 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Type-2 diabetes	5A11	Discontinued in Phase 2	[1]

Cross-matching ID

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Gastric inhibitory polypeptide receptor (GIPR)	TTYMKBE	GIPR_HUMAN	Modulator	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Gastric inhibitory polypeptide receptor (GIPR)	DTT	GIPR	3.511	2.907	1.585	1

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Type-2 diabetes

ICD Disease Classification

5A11

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Gastric inhibitory polypeptide receptor (GIPR)	DTT	GIPR	6.53E-02	-0.19	-1.27

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800034341)
2	Company report (Roche pipeline: 16 October 2014)