Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMI2XUQ)

Drug Name

6-Allyloxy-9H-purin-2-ylamine Drug Info

Synonyms

CHEMBL325053; 50663-54-2; O6-Allylguanine; O6-Substituted Guanine Deriv. 15; 6-prop-2-enoxy-7H-purin-2-amine; NU 2028; AC1L45IB; SCHEMBL1263549; BDBM5475; 6-(prop-2-en-1-yloxy)-9H-purin-2-amine; 9H-Purin-2-amine, 6-(2-propen-1-yloxy)-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 179571
CAS Number: CAS 50663-54-2
TTD Drug ID: DMI2XUQ

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
O-6-methylguanine-DNA-alkyltransferase (MGMT)	TTJ8DV7	MGMT_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
O-6-methylguanine-DNA-alkyltransferase (MGMT)	DTT	MGMT	8.185	5.44	6.509	5.333

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
O-6-methylguanine-DNA-alkyltransferase (MGMT)	DTT	MGMT	1.21E-12	-0.31	-0.83

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Resistance-modifying agents. 8. Inhibition of O(6)-alkylguanine-DNA alkyltransferase by O(6)-alkenyl-, O(6)-cycloalkenyl-, and O(6)-(2-oxoalkyl)gua... J Med Chem. 2000 Nov 2;43(22):4071-83.