Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMI580M)

Drug Name

4-Chloro-5,7-diphenyl-7H-pyrrolo[2,3-d]pyrimidine Drug Info

Synonyms

4-Chloro-5,7-diphenyl-7H-pyrrolo[2,3-d]pyrimidine; 4-chloro-5,7-diphenylpyrrolo[2,3-d]pyrimidine; 287177-10-0; CHEMBL426229; AC1M1GSW; MolPort-000-510-379; ZINC2455203; BDBM50088916; SBB039474; BBL001718; STL115578; AKOS000267629; MCULE-6403159172; ST45174715; H6707; L-3752

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 2049536
TTD Drug ID: DMI580M

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Proto-oncogene c-Src (SRC)	TT6PKBN	SRC_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Proto-oncogene c-Src (SRC)	DTT	SRC	2.907	3.35	3.498	4.75

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Proto-oncogene c-Src (SRC)	DTT	SRC	6.45E-01	-0.08	-0.58
Proto-oncogene c-Src (SRC)	DTT	SRC	2.08E-03	-0.52	-1.62

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Substituted 5,7-diphenyl-pyrrolo[2,3d]pyrimidines: potent inhibitors of the tyrosine kinase c-Src. Bioorg Med Chem Lett. 2000 May 1;10(9):945-9.