Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMI8217)

Drug Name

PMID22136433C20 Drug Info

Synonyms

NSC748497; NSC-748497; KH-CARB13; GTPL8156; BDBM50363167

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Calmodulin-dependent kinase II (CAMKK2)	TTV298Y	KKCC2_HUMAN	Inhibitor	[1]
PIM-3 protein kinase (PIM3)	TTCGOIN	PIM3_HUMAN	Inhibitor	[1]
Protein kinase N1 (PKN1)	TTSL41O	PKN1_HUMAN	Inhibitor	[1]
Serine/threonine-protein kinase pim-1 (PIM1)	TTTN5QW	PIM1_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Serine/threonine-protein kinase pim-1 (PIM1)	DTT	PIM1	8.975	6.811	6.737	8.01

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Serine/threonine-protein kinase pim-1 (PIM1)	DTT	PIM1	4.83E-01	0.06	0.2
PIM-3 protein kinase (PIM3)	DTT	PIM3	7.86E-06	0.78	3.44

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	7,8-dichloro-1-oxo-beta-carbolines as a versatile scaffold for the development of potent and selective kinase inhibitors with unusual binding modes. J Med Chem. 2012 Jan 12;55(1):403-13.