Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMI8T1Y)

Drug Name

PMID24809814C31 Drug Info

Synonyms

4q6r; GTPL8465; BDBM50018282; 30J

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Sphingosine-1-phosphate lyase 1 (SGPL1)	TT618Q2	SGPL1_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Sphingosine-1-phosphate lyase 1 (SGPL1)	DTT	SGPL1	5.672	6.215	6.403	6.711

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Sphingosine-1-phosphate lyase 1 (SGPL1)	DTT	SGPL1	1.63E-02	0.38	0.9

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Orally active 7-substituted (4-benzylphthalazin-1-yl)-2-methylpiperazin-1-yl]nicotinonitriles as active-site inhibitors of sphingosine 1-phosphate lyase for the treatment of multiple sclerosis. J MedChem. 2014 Jun 26;57(12):5074-84.