Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMIEB8Y)

Drug Name

Bevasiranib Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Exudative age-related macular degeneration	9B78.3Z	Discontinued in Phase 3	[1]

Therapeutic Class

siRNA

Cross-matching ID

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Vascular endothelial growth factor A (VEGFA)	TTOHSBA	VEGFA_HUMAN	Modulator	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Vascular endothelial growth factor A (VEGFA)	DTT	VEGFA	8.544	6.927	7.253	7.839

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Exudative age-related macular degeneration

ICD Disease Classification

9B78.3Z

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Vascular endothelial growth factor A (VEGFA)	DTT	VEGFA	3.61E-01	0.15	0.47

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	2011 Pipeline of Acuity Pharmaceuticals.
2	Bevasiranib for the Treatment of Wet, Age-Related Macular Degeneration